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A Phase 1, Open-Label, Dose-Escalation and Expansion Study of AGX101, a TM4SF1 Directed Antibody Drug Conjugate in Patients with Unresectable, Locally Advanced, or Metastatic Solid Tumors

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Trial Profile

A Phase 1, Open-Label, Dose-Escalation and Expansion Study of AGX101, a TM4SF1 Directed Antibody Drug Conjugate in Patients with Unresectable, Locally Advanced, or Metastatic Solid Tumors

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 20 Mar 2025

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At a glance

  • Drugs AGX 101 (Primary)
  • Indications Solid tumours
  • Focus Adverse reactions; First in man
  • Sponsors Angiex

    • Most Recent Events

    • 19 Sep 2024 Planned End Date changed from 1 May 2027 to 1 Jul 2027.
    • 19 Sep 2024 Planned primary completion date changed from 1 May 2025 to 1 Jul 2025.
    • 08 Aug 2024 According to an Abzena media release, Angiex partnered with Abzena, the leading end-to-end integrated CDMO for complex biologics and bioconjugates, to support the development, manufacture and supply of clinical trial material for the study.

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