Trial Profile

REVERT- Liver Cancer: A Phase 1b/2 Multicenter, Open-label Study to Evaluate the Safety and Efficacy of TTI-101 as Monotherapy and in Combination in Participants With Locally Advanced or Metastatic, and Unresectable Hepatocellular Carcinoma

Status: Recruiting

Phase of Trial: Phase I/II

Latest Information Update: 25 May 2026

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At a glance

Drugs Atezolizumab (Primary) ; Bevacizumab (Primary) ; Pembrolizumab (Primary) ; TTI 101 (Primary)
Indications Liver cancer
Focus Adverse reactions; Therapeutic Use
Sponsors Tvardi Therapeutics

27 Apr 2026 Planned End Date changed from 28 Jun 2027 to 10 Mar 2027.
27 Apr 2026 Planned primary completion date changed from 29 Jun 2026 to 1 Feb 2027.
06 Apr 2026 Planned number of patients changed from 178 to 193.

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