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First-in-Human, Open-label, Dose-Escalation Trial With an Expansion Cohort to Evaluate the Safety of GEN1053 as Monotherapy in Subjects With Malignant Solid Tumors

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Trial Profile

First-in-Human, Open-label, Dose-Escalation Trial With an Expansion Cohort to Evaluate the Safety of GEN1053 as Monotherapy in Subjects With Malignant Solid Tumors

Status: Discontinued
Phase of Trial: Phase I/II

Latest Information Update: 24 Apr 2025

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At a glance

  • Drugs GEN-1053 (Primary)
  • Indications Carcinoma; Head and neck cancer; Ovarian cancer; Solid tumours; Squamous cell cancer
  • Focus Adverse reactions; First in man
  • Sponsors Genmab

Most Recent Events

  • 07 Jun 2024 Status changed from active, no longer recruiting to discontinued.
  • 02 Apr 2024 Planned End Date changed from 1 Jul 2027 to 1 Dec 2026.
  • 02 Apr 2024 Planned primary completion date changed from 1 Jul 2025 to 1 Sep 2026.

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