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Comparing Safety and Protective Efficacy of the Whole Plasmodium Falciparum Sporozoite Chemoprophylaxis Vaccine Candidate PfSPZ-CVac and Prime- Target Vaccination With Viral Vectored Vaccine Candidate Regime MVA ME-TRAP/ ChAd63 ME-TRAP in Malaria-naïve, Healthy Adult Volunteers in Germany

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Trial Profile

Comparing Safety and Protective Efficacy of the Whole Plasmodium Falciparum Sporozoite Chemoprophylaxis Vaccine Candidate PfSPZ-CVac and Prime- Target Vaccination With Viral Vectored Vaccine Candidate Regime MVA ME-TRAP/ ChAd63 ME-TRAP in Malaria-naïve, Healthy Adult Volunteers in Germany

Status: Not yet recruiting
Phase of Trial: Phase I/II

Latest Information Update: 10 Dec 2024

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At a glance

  • Drugs Artesunate/pyronaridine (Primary) ; Malaria vaccine live attenuated-Sanaria (Primary) ; ME-TRAP malaria DNA vaccine Okairos (Primary) ; Sodium chloride
  • Indications Falciparum malaria; Malaria
  • Focus Adverse reactions

    • Most Recent Events

    • 06 Dec 2024 Planned End Date changed from 30 Oct 2025 to 30 Jun 2026.
    • 06 Dec 2024 Planned primary completion date changed from 30 Oct 2025 to 30 Jun 2026.
    • 06 Dec 2024 Planned initiation date changed from 1 Oct 2024 to 1 Jun 2025.

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