Trial Profile

A Phase 3, Multi-center, Randomized, Double-blind Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Metoprolol in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy

Status: Completed

Phase of Trial: Phase III

Latest Information Update: 17 Feb 2026

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At a glance

10 Nov 2025 According to Cytokinetics media release, data from the trial were presented at the Hypertrophic Cardiomyopathy Medical Society Scientific Sessions and the American Heart Association Scientific Sessions 2025 in New Orleans, LA. Two of the presentations were simultaneously published in the Journal of the American College of Cardiology.1,2
10 Nov 2025 Results presented in the Cytokinetics Media Release
06 Nov 2025 According to Cytokinetics media release, Supplemental analyses of MAPLE-HCM presented at the Heart Failure Society of America (HFSA) Annual Scientific Meeting 2025.

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