Trial Profile

A Phase 3, Multi-center, Randomized, Double-blind Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Metoprolol in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy

Status: Completed

Phase of Trial: Phase III

Latest Information Update: 19 May 2025

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At a glance

Drugs Aficamten (Primary) ; Metoprolol succinate
Indications Hypertrophic cardiomyopathy
Focus Registrational; Therapeutic Use
Acronyms MAPLE-HCM
Sponsors Cytokinetics

Most Recent Events

13 May 2025 Primary endpoint (Change in peak oxygen uptake (pVO2) by cardiopulmonary exercise testing (CPET)) has been met.
13 May 2025 According to a Cytokinetics media release, the full results from MAPLE-HCM will be presented at an upcoming medical conference.
13 May 2025 Results presented in a Cytokinetics media release.

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