Trial Profile

A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Sefaxersen, an Antisense Inhibitor of Complement Factor B, in Patients With Primary IgA Nephropathy at High Risk of Progression

Status: Recruiting

Phase of Trial: Phase III

Latest Information Update: 19 Feb 2026

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At a glance

07 Oct 2025 According to an Ionis Pharmaceuticals media release, data from the IMAGINATION study of sefaxersen for IgA nephropathy (IgAN) are expected in 2026 (Roche).
04 Jun 2025 Planned End Date changed from 30 Sep 2030 to 31 Mar 2029.
04 Jun 2025 Planned primary completion date changed from 31 Jul 2026 to 31 Aug 2026.

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