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A Phase 1, Open-label, Multicohort Study to Evaluate the Impact of Inhibitors and Inducers of Cytochrome P450 Enzyme (CYP)3A, P-glycoprotein (P-gp), and Breast Cancer Resistant Protein (BCRP) on the Pharmacokinetics (PK) of Vesatolimod (VES) in Virologically Suppressed Adults With HIV-1 on Antiretroviral Therapy (ART)

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Trial Profile

A Phase 1, Open-label, Multicohort Study to Evaluate the Impact of Inhibitors and Inducers of Cytochrome P450 Enzyme (CYP)3A, P-glycoprotein (P-gp), and Breast Cancer Resistant Protein (BCRP) on the Pharmacokinetics (PK) of Vesatolimod (VES) in Virologically Suppressed Adults With HIV-1 on Antiretroviral Therapy (ART)

Status: Discontinued
Phase of Trial: Phase I

Latest Information Update: 06 Dec 2024

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At a glance

  • Drugs Cobicistat (Primary) ; Rifabutin (Primary) ; Vesatolimod (Primary) ; Voriconazole (Primary)
  • Indications HIV-1 infections
  • Focus Adverse reactions; Pharmacokinetics
  • Sponsors Gilead Sciences

    • Most Recent Events

    • 13 Nov 2023 Status changed from active, no longer recruiting to discontinued.
    • 05 May 2023 Status changed from recruiting to active, no longer recruiting.
    • 20 Mar 2023 Planned End Date changed from 1 May 2023 to 1 Nov 2023.

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