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ANGIO-A: Safety and Tolerability of Oral Cyclophosphamide and Sorafenib With Intravenous Bevacizumab With the Addition of Atezolizumab in Pediatric Solid Tumor Patients

Trial Profile

ANGIO-A: Safety and Tolerability of Oral Cyclophosphamide and Sorafenib With Intravenous Bevacizumab With the Addition of Atezolizumab in Pediatric Solid Tumor Patients

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 18 Mar 2026

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At a glance

  • Drugs Atezolizumab (Primary) ; Bevacizumab (Primary) ; Cyclophosphamide (Primary) ; Sorafenib (Primary)
  • Indications Liver cancer; Solid tumours
  • Focus Adverse reactions; Pharmacodynamics; Pharmacokinetics; Therapeutic Use
  • Acronyms ANGIO-A

Most Recent Events

  • 18 Feb 2026 Status changed from suspended to recruiting.
  • 25 May 2025 Status changed from recruiting to suspended. (Temporary closure due to review of toxicity )
  • 29 Mar 2024 Results determining if SOR systemic exposure can be targeted to an AUC by day 21 of course 1 in 60 percent of patients when given in combination with CTX, BEV, and ATZ, presented at the 125th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics

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