Trial Profile

A Randomized, Open-label Study of Serplulimab Plus Chemotherapy (Carboplatin-Etoposide) in Comparison With Atezolizumab Plus Chemotherapy in Previously Untreated US Patients With Extensive Stage Small Cell Lung Cancer (ES-SCLC) (ASTRIDE)

Status: Active, no longer recruiting

Phase of Trial: Phase III

Latest Information Update: 24 Oct 2025

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At a glance

Drugs Carboplatin (Primary) ; Etoposide (Primary) ; Serplulimab (Primary) ; Atezolizumab
Indications Small cell lung cancer
Focus Adverse reactions; Registrational
Acronyms ASTRIDE
Sponsors Shanghai Henlius Biotech

22 Oct 2025 According to a Shanghai Henlius Biotech media release, enrolment of all 200 patients in this trial has been completed
21 Oct 2025 Planned End Date changed from 31 Dec 2025 to 31 Dec 2027.
21 Oct 2025 Planned primary completion date changed from 30 Sep 2025 to 28 Feb 2026.

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