Assessment of Safety and Feasibility of Exablate Blood-Brain Barrier Disruption for the Treatment of Patients With Mild Cognitive Impairment (MCI) or Mild Alzheimer's Disease (AD) Undergoing Standard of Care Monoclonal Antibody (mAb) Therapy
Latest Information Update: 22 Feb 2024
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At a glance
- Drugs Aducanumab (Primary) ; Lecanemab (Primary)
- Indications Alzheimer's disease; Mild cognitive impairment
- Focus Adverse reactions
- 31 Jan 2024 According to a Biogen media release, company will discontinue the development and commercialization of ADUHELM (aducanumab-avwa) 100 mg/mL injection for intravenous use.
- 04 Jan 2024 Results of focused ultrasound with each of six monthly aducanumab infusions to temporarily open the blood-brain barrier with the goal of enhancing amyloid removal in selected brain regions in three participants over a period of 6 months, published in the New England Journal of Medicine
- 19 Dec 2023 Lecanemab is added to the study drugs.