Trial Profile

A 2-Part Seamless Part A (Phase 2)/Part B (Phase 3) Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of BIIB059 in Participants with Active Subacute Cutaneous Lupus Erythematosus and/or Chronic Cutaneous Lupus Erythematosus with or without Systemic Manifestations and Refractory and/or Intolerant to Antimalarial Therapy (AMETHYST)

Status: Recruiting

Phase of Trial: Phase II/III

Latest Information Update: 14 Mar 2026

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At a glance

23 Feb 2026 Planned number of patients changed from 613 to 450.
28 Jan 2026 According to a Biogen media release, a data readout from this trial is expected in 2027.
02 Sep 2022 Planned End Date changed from 18 Oct 2026 to 13 Dec 2026.

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