Trial Profile

A Phase 1 Dose Escalation and Expansion Study of EO-3021, an Anti-claudin 18.2 (CLDN18.2) Antibody Drug Conjugate, in Patients With Solid Tumors Likely to Express CLDN18.2

Status: Discontinued

Phase of Trial: Phase I

Latest Information Update: 14 Jul 2025

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At a glance

Drugs Dostarlimab (Primary) ; Ramucirumab (Primary) ; SYSA 1801 (Primary)
Indications Adenocarcinoma; Gastric cancer; Lung cancer; Oesophageal cancer; Pancreatic cancer; Solid tumours
Focus Adverse reactions
Sponsors Elevation Oncology

20 Mar 2025 According to an Elevation Oncology media release, the company discontinue further development of EO-3021 based on data from the dose escalation and expansion stages of Elevation Oncology's Phase 1 trial.
20 Mar 2025 Status changed from recruiting to discontinued.
13 Jan 2025 According to an Elevation Oncology media release, the company has started dosing in combination portion of the trial and expect to report initial data from combination cohort in 4Q 2025 or 1Q 2026.

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