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A Phase 1, Safety Lead-In and Randomized, Open-label, Perioperative Study of Vorasidenib in Combination With Pembrolizumab in Subjects With Recurrent or Progressive IDH-1 Mutant Glioma

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Trial Profile

A Phase 1, Safety Lead-In and Randomized, Open-label, Perioperative Study of Vorasidenib in Combination With Pembrolizumab in Subjects With Recurrent or Progressive IDH-1 Mutant Glioma

Status: Active, no longer recruiting
Phase of Trial: Phase I

Latest Information Update: 16 Mar 2026

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At a glance

  • Drugs Pembrolizumab (Primary) ; Vorasidenib (Primary)
  • Indications Glioma
  • Focus Adverse reactions; Therapeutic Use
  • Sponsors Institut de Recherches Internationales Serviers

Most Recent Events

  • 12 Mar 2026 Status changed from recruiting to active, no longer recruiting.
  • 03 Jun 2025 Planned primary completion date changed from 31 Mar 2025 to 31 Jan 2026.
  • 04 Jun 2024 Planned primary completion date changed from 28 Feb 2025 to 31 Mar 2025.

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