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Study for Safety and Efficacy Evaluation of Olverembatinib Combined With APG-2575 in Children With Relapsed/Refractory Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia (R/R Ph + ALL)

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Trial Profile

Study for Safety and Efficacy Evaluation of Olverembatinib Combined With APG-2575 in Children With Relapsed/Refractory Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia (R/R Ph + ALL)

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 01 Sep 2026

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At a glance

  • Drugs Dexamethasone (Primary) ; Lisaftoclax (Primary) ; Olverembatinib (Primary)
  • Indications Acute myeloid leukaemia
  • Focus Adverse reactions; Pharmacokinetics; Therapeutic Use

Most Recent Events

  • 26 Aug 2026 Planned number of patients changed from 22 to 19.
  • 26 Aug 2026 Planned End Date changed from 1 Dec 2024 to 1 Dec 2027.
  • 26 Aug 2026 Planned primary completion date changed from 31 Aug 2024 to 31 Dec 2026.

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