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An Open-label Study to Evaluate the Impact of Omeprazole, A Proton Pump Inhibitor, on the Pharmacokinetics of Sotorasib Co-administered With an Acidic Beverage in Healthy Volunteers

Trial Profile

An Open-label Study to Evaluate the Impact of Omeprazole, A Proton Pump Inhibitor, on the Pharmacokinetics of Sotorasib Co-administered With an Acidic Beverage in Healthy Volunteers

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 23 Jan 2024

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At a glance

  • Drugs Omeprazole (Primary) ; Sotorasib (Primary)
  • Indications Colorectal cancer; Non-small cell lung cancer; Pancreatic cancer; Solid tumours
  • Focus Pharmacokinetics
  • Sponsors Amgen
  • Most Recent Events

    • 19 Apr 2023 Results evaluating if taking sotorasib with an acidic beverage such as Coca Cola would alter sotorasib absorption when coadministered with omeprazole and improve sotorasib exposure presented at the 114th Annual Meeting of the American Association for Cancer Research
    • 13 Sep 2022 Status changed from active, no longer recruiting to completed.
    • 29 Aug 2022 Status changed from recruiting to active, no longer recruiting.

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