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Pilot Study on the Infusion of Differentiated Autologous T-cells From Peripheral Blood, Expanded and Transduced With a Lentivirus to Express a Chimeric Antigen Receptor With Anti-CD19 Specificity Conjugated With the Co-stimulatory Regions 4-1BB and CD3z in Patients With CD19+ Leukemia or Lymphoma Refractory to Therapy

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Trial Profile

Pilot Study on the Infusion of Differentiated Autologous T-cells From Peripheral Blood, Expanded and Transduced With a Lentivirus to Express a Chimeric Antigen Receptor With Anti-CD19 Specificity Conjugated With the Co-stimulatory Regions 4-1BB and CD3z in Patients With CD19+ Leukemia or Lymphoma Refractory to Therapy

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 23 Sep 2024

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At a glance

  • Drugs Varnimcabtagene-Autoleucel (Primary)
  • Indications B-cell lymphoma; Chronic lymphocytic leukaemia; Diffuse large B cell lymphoma; Follicular lymphoma; Mantle-cell lymphoma; Non-Hodgkin's lymphoma; Precursor cell lymphoblastic leukaemia-lymphoma
  • Focus Adverse reactions; First in man
  • Acronyms CART19-BE-01

Most Recent Events

  • 01 Feb 2024 Results of updated outcomes published in the British Journal of Haematology.
  • 12 Dec 2023 Results assessing long-term remission in CLL patients treated with CART19 therapy, presented at the 65th American Society of Hematology Annual Meeting and Exposition.
  • 12 Dec 2023 Results of an intention to treat analysis using CAR-T cell product data from CART19-BE-01 trial and consecutive compassionate use and hospital exemption programs presented at the 65th American Society of Hematology Annual Meeting and Exposition

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