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Phase 2 Study With Safety run-in of PD-1 Inhibitor and IgG4 SIRPα-Fc Fusion Protein (TTI-622) in Relapsed Diffuse Large B-Cell Lymphoma (DLBCL)

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Trial Profile

Phase 2 Study With Safety run-in of PD-1 Inhibitor and IgG4 SIRPα-Fc Fusion Protein (TTI-622) in Relapsed Diffuse Large B-Cell Lymphoma (DLBCL)

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 01 Oct 2025

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At a glance

  • Drugs Maplirpacept (Primary) ; Ontorpacept (Primary) ; Pembrolizumab (Primary)
  • Indications B-cell lymphoma; Diffuse large B cell lymphoma; Follicular lymphoma; T-cell lymphoma
  • Focus Adverse reactions; Therapeutic Use

Most Recent Events

  • 29 Aug 2025 Planned End Date changed from 1 Nov 2027 to 30 Jul 2027.
  • 29 Aug 2025 Planned primary completion date changed from 1 Nov 2026 to 30 Jul 2027.
  • 29 Aug 2025 Status changed from recruiting to active, no longer recruiting.

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