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A Two Part Phase IIa/b Multicentre, Randomised, Double-Blind, Placebo-Controlled, Parallel Group Dose-ranging Study to Assess Efficacy, Safety, and Tolerability of the Combination of Zibotentan and Dapagliflozin, and Dapagliflozin Monotherapy Versus Placebo in Participants With Cirrhosis With Features of Portal Hypertension

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Trial Profile

A Two Part Phase IIa/b Multicentre, Randomised, Double-Blind, Placebo-Controlled, Parallel Group Dose-ranging Study to Assess Efficacy, Safety, and Tolerability of the Combination of Zibotentan and Dapagliflozin, and Dapagliflozin Monotherapy Versus Placebo in Participants With Cirrhosis With Features of Portal Hypertension

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 11 Jun 2025

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At a glance

  • Drugs Dapagliflozin (Primary) ; Zibotentan (Primary)
  • Indications Liver cirrhosis
  • Focus Therapeutic Use
  • Acronyms ZEAL; ZEAL Study
  • Sponsors AstraZeneca

Most Recent Events

  • 04 Jun 2025 Planned End Date changed from 18 Aug 2025 to 15 Aug 2025.
  • 04 Jun 2025 Status changed from recruiting to active, no longer recruiting.
  • 03 Jan 2025 Planned End Date changed from 16 Apr 2025 to 18 Aug 2025.

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