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Phase 1/2 Study of mRNA-4359 Administered Alone and in Combination With Immune Checkpoint Blockade in Participants With Advanced Solid Tumors

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Trial Profile

Phase 1/2 Study of mRNA-4359 Administered Alone and in Combination With Immune Checkpoint Blockade in Participants With Advanced Solid Tumors

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 24 Aug 2026

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At a glance

  • Drugs Ipilimumab (Primary) ; MRNA-4359 (Primary) ; Nivolumab (Primary) ; Pembrolizumab (Primary) ; Sodium chloride
  • Indications Advanced breast cancer; Basal cell cancer; Bladder cancer; Carcinoma; Colorectal cancer; Head and neck cancer; Malignant melanoma; Non-small cell lung cancer; Solid tumours; Squamous cell cancer; Triple negative breast cancer
  • Focus Adverse reactions; First in man; Therapeutic Use
  • Sponsors Moderna Therapeutics

Most Recent Events

  • 01 May 2026 According to Moderna Therapeutics media release, . The Company recently presented mRNA-4359 data at the American Association for Cancer Research (AACR) 2026 Annual Meeting.
  • 17 Apr 2026 Results presented in the Moderna Therapeutics media release.
  • 17 Apr 2026 According to Moderna Therapeutics media release, data from this trial will be presented at the American Association for Cancer Research (AACR) Annual Meeting in San Diego, CA, on April 17-22, 2026.

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