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A Phase IB and Randomized Phase II Trial of Megestrol Acetate With or Without Ipatasertib in Recurrent or Metastatic Endometrioid Endometrial Cancer

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Trial Profile

A Phase IB and Randomized Phase II Trial of Megestrol Acetate With or Without Ipatasertib in Recurrent or Metastatic Endometrioid Endometrial Cancer

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 01 Jan 2026

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At a glance

  • Drugs Ipatasertib (Primary) ; Megestrol (Primary)
  • Indications Adenocarcinoma; Endometrial cancer
  • Focus Adverse reactions; Therapeutic Use

Most Recent Events

  • 03 Jul 2025 Status changed from recruiting to active, no longer recruiting.
  • 27 Feb 2024 Status changed from suspended to recruiting.
  • 15 Feb 2024 The protocol has been amended in Megestrol acetate dose frequency changes from days 1 to 28 and ipatasertib PO QD dose changes from days 1 to21 of every cycle.

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