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A Phase 3, Randomized, Active-Controlled, Double-Blind Clinical Study to Evaluate a Switch to Doravirine/Islatravir (DOR/ISL 100 mg/0.25 mg) Once-Daily in Participants With HIV-1 Who Are Virologically Suppressed on Bictegravir/Emtricitabine/Tenofovir Alafenamide (BIC/FTC/TAF)

Trial Profile

A Phase 3, Randomized, Active-Controlled, Double-Blind Clinical Study to Evaluate a Switch to Doravirine/Islatravir (DOR/ISL 100 mg/0.25 mg) Once-Daily in Participants With HIV-1 Who Are Virologically Suppressed on Bictegravir/Emtricitabine/Tenofovir Alafenamide (BIC/FTC/TAF)

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 19 Mar 2025

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At a glance

  • Drugs Doravirine/islatravir (Primary) ; Bictegravir/emtricitabine/tenofovir alafenamide
  • Indications HIV-1 infections
  • Focus Adverse reactions; Registrational; Therapeutic Use
  • Sponsors Merck & Co; Merck Sharp & Dohme
  • Most Recent Events

    • 12 Mar 2025 According to Merck & Co media release, data from this trial will be presented at the 32nd Conference on Retroviruses and Opportunistic Infections (CROI)
    • 12 Mar 2025 Results presented in the Merck & Co Media Release
    • 19 Dec 2024 According to Merck Media Release, Primary endpoint (Percentage of participants with HIV-1 RNA 50 copies/mL at Week 48 [ Time Frame: Week 48 ])has been met.

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