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A Phase 2b Clinical Study of the P38 Alpha Kinase Inhibitor Neflamapimod in Patients with Dementia with Lewy Bodies

Trial Profile

A Phase 2b Clinical Study of the P38 Alpha Kinase Inhibitor Neflamapimod in Patients with Dementia with Lewy Bodies

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 18 May 2025

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At a glance

  • Drugs Neflamapimod (Primary)
  • Indications Lewy body disease
  • Focus Proof of concept; Therapeutic Use
  • Acronyms RewinD-LB
  • Sponsors CervoMed; EIP Pharma

Most Recent Events

  • 02 Apr 2025 According to a CervoMed media release, the company expects to complete the full 32-weeks of the Extension phase of the RewinD-LB study and engage with regulatory authorities to discuss finalizing Phase 3 plans for neflamapimod after these additional data become available later in 2H 2025.
  • 02 Apr 2025 According to a CervoMed media release, company announced that investigators plan to present results, including new results, from the Extension phase of the Phase 2b RewinD-LB study that show neflamapimod demonstrated a clinically meaningful effect on slowing clinical progression in patients with DLB in an oral presentation during the 19th International Conference on Alzheimers and Parkinsons Disease and Related Neurologic Disorders (AP/PD™) on Saturday, April 5, 2025.
  • 02 Apr 2025 Results presented in the CervoMed media release.

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