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A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Patients With Severe Hypertriglyceridemia

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Trial Profile

A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Patients With Severe Hypertriglyceridemia

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 11 May 2025

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At a glance

  • Drugs Olezarsen (Primary)
  • Indications Hypertriglyceridaemia
  • Focus Registrational; Therapeutic Use
  • Acronyms CORE-2
  • Sponsors Ionis Pharmaceuticals

Most Recent Events

  • 30 Apr 2025 According to Ionis pharmaceutical media release, topline phase 3 data expected in Q3 2025.
  • 30 Apr 2025 According to Ionis Pharmaceuticals media release, study design and baseline characteristics for CORE, CORE2 and ESSENCE studies were published in the American Heart Journal.
  • 29 Jan 2025 Planned End Date changed from 1 Jul 2025 to 1 Sep 2025.

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