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A Phase 1, Randomized, Double-blind, Placebo-controlled, Safety, Tolerability, and Pharmacokinetic Study of Single Ascending Doses and Multiple Doses of WVE-006 in Healthy Participants

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Trial Profile

A Phase 1, Randomized, Double-blind, Placebo-controlled, Safety, Tolerability, and Pharmacokinetic Study of Single Ascending Doses and Multiple Doses of WVE-006 in Healthy Participants

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 08 May 2025

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At a glance

  • Drugs WVE-006 (Primary)
  • Indications Alpha 1-antitrypsin deficiency
  • Focus Adverse reactions; First in man
  • Acronyms RestorAATion 1
  • Sponsors WaVe life Sciences

Most Recent Events

  • 29 Apr 2025 Status changed from recruiting to completed.
  • 13 Jan 2025 According to WAVE Life Sciences Ltd. media release, multi-dosing of healthy volunteers in the top cohort completed in this study at a dose level greater than those planned for any cohort of the RestorAATion-2 patient study..
  • 08 Jan 2024 According to WAVE Life Sciences Ltd. media release, with initiation of dosing in RestorAATion, Wave achieved its first WVE-006 milestone under the collaboration, resulting in a $20 million payment from GSK. Wave is eligible to receive up to $505 million in additional development, launch, and commercial milestone payments, as well as tiered royalties on net sales, from GSK for WVE-006.

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