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A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of LY3819469 in Adults With Elevated Lipoprotein(a)

Trial Profile

A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of LY3819469 in Adults With Elevated Lipoprotein(a)

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 02 Jun 2025

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At a glance

  • Drugs Lepodisiran (Primary)
  • Indications Hyperlipoproteinaemia
  • Focus Therapeutic Use
  • Acronyms ALPACA
  • Sponsors Eli Lilly and Company

Most Recent Events

  • 30 Mar 2025 According to Eli Lilly and Company Media Release, data of this trial were presented at the American College of Cardiology 2025 Scientific Sessions and simultaneously published in the New England Journal of Medicine (NEJM)
  • 30 Mar 2025 According to Eli Lilly and Company Media Release, company announced positive Phase 2 results for lepodisiran, an investigational small interfering RNA (siRNA) therapy designed to lower the production of lipoprotein(a) [Lp(a)], a genetically inherited risk factor for heart disease.
  • 30 Mar 2025 Results published in the Eli Lilly and Company Media Release

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