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Neoadjuvant Treatment With mFOLFOXIRI Plus Cadonilimab (AK104) Versus mFOLFOX6 Alone in Locally Advanced Colorectal Cancer: a Randomized Control Phase II Study (OPTICAL-2)

Trial Profile

Neoadjuvant Treatment With mFOLFOXIRI Plus Cadonilimab (AK104) Versus mFOLFOX6 Alone in Locally Advanced Colorectal Cancer: a Randomized Control Phase II Study (OPTICAL-2)

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 05 Jan 2024

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At a glance

  • Drugs Cadonilimab (Primary) ; Fluorouracil (Primary) ; Folinic acid (Primary) ; Irinotecan (Primary) ; Oxaliplatin (Primary)
  • Indications Adenocarcinoma; Colorectal cancer
  • Focus Therapeutic Use
  • Acronyms OPTICAL-2

Most Recent Events

  • 26 Dec 2023 Number of treatment arms are increased from 2 to 3 by the addition of Active Comparator: mFOLFOXIRI arm.
  • 26 Dec 2023 Planned number of patients changed from 82 to 143.
  • 26 Dec 2023 Status changed from not yet recruiting to recruiting.

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