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TACTIVE-U: AN INTERVENTIONAL SAFETY AND EFFICACY PHASE 1B/2, OPEN-LABEL UMBRELLA STUDY TO INVESTIGATE TOLERABILITY, PK, AND ANTITUMOR ACTIVITY OF ARV-471 (PF-07850327), AN ORAL PROTEOLYSIS TARGETING CHIMERA, IN COMBINATION WITH OTHER ANTICANCER TREATMENTS IN PARTICIPANTS AGED 18 YEARS AND OVER WITH ER+ ADVANCED OR METASTATIC BREAST CANCER, SUB-STUDY B (ARV-471 IN COMBINATION WITH RIBOCICLIB)

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Trial Profile

TACTIVE-U: AN INTERVENTIONAL SAFETY AND EFFICACY PHASE 1B/2, OPEN-LABEL UMBRELLA STUDY TO INVESTIGATE TOLERABILITY, PK, AND ANTITUMOR ACTIVITY OF ARV-471 (PF-07850327), AN ORAL PROTEOLYSIS TARGETING CHIMERA, IN COMBINATION WITH OTHER ANTICANCER TREATMENTS IN PARTICIPANTS AGED 18 YEARS AND OVER WITH ER+ ADVANCED OR METASTATIC BREAST CANCER, SUB-STUDY B (ARV-471 IN COMBINATION WITH RIBOCICLIB)

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 19 Feb 2025

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At a glance

  • Drugs Ribociclib (Primary) ; Vepdegestrant (Primary)
  • Indications Advanced breast cancer; HER2 negative breast cancer; Male breast cancer
  • Focus Adverse reactions; Pharmacokinetics; Therapeutic Use
  • Acronyms Sub-Study B; TACTIVE-U
  • Sponsors Pfizer

    • Most Recent Events

    • 11 Feb 2025 Planned End Date changed from 6 Jan 2027 to 30 Dec 2026.
    • 11 Feb 2025 Planned primary completion date changed from 6 Jan 2027 to 30 Dec 2026.
    • 11 Feb 2025 According to an Arvinas media release, the company expects submit key data for presentation at medical conference in 2025.

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