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A PHASE 2, RANDOMIZED, DOUBLE-BLIND, PLACEBO CONTROLLED, DOSE RANGING, DOSE FINDING, PARALLEL GROUP STUDY TO ASSESS EFFICACY AND SAFETY OF PF-07081532, AND OPEN LABEL ORAL SEMAGLUTIDE, IN ADULTS WITH TYPE 2 DIABETES MELLITUS (T2DM) INADEQUATELY CONTROLLED ON METFORMIN, AND SEPARATELY PF-07081532 COMPARED TO MATCHING PLACEBO IN ADULTS WITH OBESITY BUT WITHOUT T2DM

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Trial Profile

A PHASE 2, RANDOMIZED, DOUBLE-BLIND, PLACEBO CONTROLLED, DOSE RANGING, DOSE FINDING, PARALLEL GROUP STUDY TO ASSESS EFFICACY AND SAFETY OF PF-07081532, AND OPEN LABEL ORAL SEMAGLUTIDE, IN ADULTS WITH TYPE 2 DIABETES MELLITUS (T2DM) INADEQUATELY CONTROLLED ON METFORMIN, AND SEPARATELY PF-07081532 COMPARED TO MATCHING PLACEBO IN ADULTS WITH OBESITY BUT WITHOUT T2DM

Status: Discontinued
Phase of Trial: Phase II

Latest Information Update: 23 Dec 2024

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At a glance

  • Drugs Lotiglipron (Primary) ; Semaglutide
  • Indications Obesity; Type 2 diabetes mellitus
  • Focus Therapeutic Use
  • Sponsors Pfizer

Most Recent Events

  • 01 Jan 2025 According to abstract published in the Diabetes, Obesity and Metabolism , Primary endpoint (Placebo-adjusted, percent change from baseline in body weight at Week 32 in Obesity) has been met.
  • 01 Jan 2025 According to abstract published in the Diabetes, Obesity and Metabolism , Primary endpoint (Placebo-adjusted, change from baseline in Hemoglobin A1c (HbA1c) at Week 32 in Type 2 Diabetes Mellitus (T2DM)) has been met.
  • 01 Jan 2025 Results investigating efficacy and safety of lotiglipron , published in the Diabetes, Obesity and Metabolism

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