Trial Profile

A Single-Arm, Phase II Study of Autophagy Modulation Using Hydroxychloroquine in Combination With Encorafenib and Cetuximab or Panitumumab in Metastatic BRAF-mutated Colorectal Cancer Refractory to Standard Therapies

Status: Recruiting

Phase of Trial: Phase II

Latest Information Update: 28 Oct 2025

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At a glance

Drugs Cetuximab (Primary) ; Encorafenib (Primary) ; Hydroxychloroquine (Primary) ; Panitumumab (Primary)
Indications Colorectal cancer
Focus Therapeutic Use

20 Oct 2025 Planned End Date changed from 1 Jul 2025 to 1 Jul 2028.
20 Oct 2025 Planned primary completion date changed from 1 Jul 2024 to 1 Jul 2026.
16 Nov 2022 Status changed from not yet recruiting to recruiting.

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