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A Multicenter, Open-Label, Phase Ib/II Study of AK119 and AK112 With or Without Chemotherapy in Patients With EGFR-mutant Locally Advanced or Metastatic Non-squamous Non-small Cell Lung Cancer Who Have Failed to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor (EGFR-TKI) Treatment

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Trial Profile

A Multicenter, Open-Label, Phase Ib/II Study of AK119 and AK112 With or Without Chemotherapy in Patients With EGFR-mutant Locally Advanced or Metastatic Non-squamous Non-small Cell Lung Cancer Who Have Failed to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor (EGFR-TKI) Treatment

Status: Discontinued
Phase of Trial: Phase I/II

Latest Information Update: 12 Mar 2026

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At a glance

  • Drugs Dresbuxelimab (Primary) ; Ivonescimab (Primary)
  • Indications Solid tumours
  • Focus Adverse reactions; Therapeutic Use
  • Sponsors Akeso Biopharma

Most Recent Events

  • 09 Mar 2026 Status changed from recruiting to discontinued.
  • 07 Mar 2023 Status changed from not yet recruiting to recruiting.
  • 20 Oct 2022 New trial record

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