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International Sites: CONNECTS Master Protocol for Clinical Trials Targeting Macro-, Micro-immuno-thrombosis, Vascular Hyperinflammation, and Hypercoagulability and Renin-angiotensin-aldosterone System (RAAS) in Hospitalized Patients With COVID-19 (ACTIV-4 Host Tissue)

Trial Profile

International Sites: CONNECTS Master Protocol for Clinical Trials Targeting Macro-, Micro-immuno-thrombosis, Vascular Hyperinflammation, and Hypercoagulability and Renin-angiotensin-aldosterone System (RAAS) in Hospitalized Patients With COVID-19 (ACTIV-4 Host Tissue)

Status: Discontinued
Phase of Trial: Phase II/III

Latest Information Update: 04 May 2025

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At a glance

  • Drugs Fostamatinib (Primary)
  • Indications COVID 2019 infections
  • Focus Therapeutic Use
  • Acronyms ACTIV-4 Host Tissue; NECTAR

Most Recent Events

  • 06 Mar 2024 Status changed from active, no longer recruiting to discontinued.
  • 07 Nov 2023 According to a Rigel Pharmaceuticals media release, the National Heart, Lung, and Blood Institute (NHLBI) has asked the trial investigators to cease enrollment, complete follow-up for participants already enrolled, and complete study closeout. The full study data will be analyzed and disseminated as previously planned.
  • 05 Oct 2023 Status changed from recruiting to active, no longer recruiting.

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