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A modular, multi-arm, first-in-human trial to evaluate the safety and tolerability of MDX-124 alone and in combination with anti-cancer treatments, in participants with locally advanced, unresectable or metastatic solid malignancies

Trial Profile

A modular, multi-arm, first-in-human trial to evaluate the safety and tolerability of MDX-124 alone and in combination with anti-cancer treatments, in participants with locally advanced, unresectable or metastatic solid malignancies

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 01 Jul 2024

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At a glance

  • Drugs MDX 124 (Primary) ; Gemcitabine; Paclitaxel
  • Indications Bladder cancer; Cholangiocarcinoma; Colorectal cancer; Gastric cancer; Liver cancer; Lung cancer; Ovarian cancer; Pancreatic cancer; Prostate cancer; Renal cancer; Solid tumours; Triple negative breast cancer
  • Focus Adverse reactions; First in man
  • Acronyms ATTAINMENT
  • Sponsors Medannex

Most Recent Events

  • 04 Jun 2024 According to trial design presented at the 60th Annual Meeting of the American Society of Clinical Oncology, Cohorts at 1, 2.5 and 5 mg/kg have been completed without DLT and enrollment to cohort 4 (10 mg/kg) began in January 2024.
  • 04 Jun 2024 Trial design presented at the 60th Annual Meeting of the American Society of Clinical Oncology.
  • 01 Dec 2022 Status changed from not yet recruiting to recruiting.

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