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A Phase 3 Randomized, Open-label Study of MK-5684 Versus Alternative Abiraterone Acetate or Enzalutamide in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) Previously Treated With Next-generation Hormonal Agent (NHA) and Taxane-based Chemotherapy

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Trial Profile

A Phase 3 Randomized, Open-label Study of MK-5684 Versus Alternative Abiraterone Acetate or Enzalutamide in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) Previously Treated With Next-generation Hormonal Agent (NHA) and Taxane-based Chemotherapy

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 07 Mar 2025

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At a glance

  • Drugs Opevesostat (Primary) ; Abiraterone acetate; Dexamethasone; Enzalutamide; Fludrocortisone; Hydrocortisone; Hydrocortisone; Prednisone
  • Indications Adenocarcinoma; Prostate cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms OMAHA1
  • Sponsors Merck Sharp & Dohme Corp.

    • Most Recent Events

    • 04 Jun 2024 Trial design, presented at the 60th Annual Meeting of the American Society of Clinical Oncology
    • 05 Jan 2024 According to a Merck & Co media release, company announced initiation of this study.
    • 05 Jan 2024 Planned End Date changed from 27 Jun 2029 to 2 Aug 2028.

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