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A Phase 2, Adaptive, Double-blinded, Placebo Controlled, Randomized, Multi-center Trial to Evaluate the Efficacy, Safety and Tolerability of Intracoronary Infusion of AB-1002 in Adult Subjects With New York Heart Association (NYHA) Class III Heart Failure and Non-ischemic Cardiomyopathy

Trial Profile

A Phase 2, Adaptive, Double-blinded, Placebo Controlled, Randomized, Multi-center Trial to Evaluate the Efficacy, Safety and Tolerability of Intracoronary Infusion of AB-1002 in Adult Subjects With New York Heart Association (NYHA) Class III Heart Failure and Non-ischemic Cardiomyopathy

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 15 Apr 2025

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At a glance

  • Drugs AB 1002 (Primary)
  • Indications Cardiomyopathies; Heart failure
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms GenePHIT
  • Sponsors Asklepios BioPharmaceutical
  • Most Recent Events

    • 13 Feb 2025 According to Bayer media release, the company announced that the first participant has been randomized in Europe in GenePHIT (Gene PHosphatase Inhibition Therapy), a Phase 2 clinical trial of AB-1002 for the treatment of congestive heart failure (CHF).
    • 28 Jun 2024 Planned End Date changed from 1 Dec 2030 to 31 Dec 2030.
    • 28 Jun 2024 Planned primary completion date changed from 1 Dec 2030 to 31 Oct 2026.

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