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A Phase 1a Open-Label, Single Ascending Dose Study to Evaluate the Safety and Tolerability of Intravitreally Administered PYC-001 in Participants With Confirmed OPA1 Mutation-Associated Autosomal Dominant Optic Atrophy

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Trial Profile

A Phase 1a Open-Label, Single Ascending Dose Study to Evaluate the Safety and Tolerability of Intravitreally Administered PYC-001 in Participants With Confirmed OPA1 Mutation-Associated Autosomal Dominant Optic Atrophy

Status: Active, no longer recruiting
Phase of Trial: Phase I

Latest Information Update: 27 Jan 2026

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At a glance

  • Drugs PYC-001 (Primary)
  • Indications Optic atrophy
  • Focus Adverse reactions; First in man
  • Sponsors PYC Therapeutics

Most Recent Events

  • 21 Jan 2026 Planned End Date changed from 1 Aug 2025 to 1 Aug 2026.
  • 21 Jan 2026 Planned primary completion date changed from 1 Jul 2025 to 1 Aug 2026.
  • 21 Jan 2026 Status changed from recruiting to active, no longer recruiting.

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