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A Randomized, Double-blind, Placebo-controlled, Multiple Ascending Dose Study to Evaluate Safety, PK and the Immunosuppressive Effects of p38 MAPK Inhibitor POLB 001 on the Intradermal and Intravenous LPS Challenge Response in Healthy Volunteers

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Trial Profile

A Randomized, Double-blind, Placebo-controlled, Multiple Ascending Dose Study to Evaluate Safety, PK and the Immunosuppressive Effects of p38 MAPK Inhibitor POLB 001 on the Intradermal and Intravenous LPS Challenge Response in Healthy Volunteers

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 06 May 2024

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At a glance

  • Drugs POLB 001 (Primary)
  • Indications Influenza virus infections
  • Focus Adverse reactions; Therapeutic Use
  • Sponsors Poolbeg Pharma

Most Recent Events

  • 30 Apr 2024 According to a Poolbeg Pharma media release, POLB 001 data presented at 65th American Society of Hematology (ASH) Annual Meeting and Exposition and the 18th International Congress of Immunology (IUIS), and garnered interest from global industry leaders in the field of bispecific antibodies and CAR T cell therapies
  • 17 Jan 2024 According to a Poolbeg Pharma media release, results data from this LPS human challenge trial, support the companys strategic expansion of the Phase II ready POLB 001 to treat and prevent cancer immunotherapy-induced CRS. The data also strengthens and facilitates the expansion of patent applications for POLB 001 in cancer immunotherapy-induced CRS.
  • 12 Dec 2023 Results reporting safety and tolerability data presented at the 65th American Society of Hematology Annual Meeting and Exposition

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