A Pilot Safety and Feasibility Study to Evaluate Motixafortide (CXCR4/SDF-1 Inhibition) and Natalizumab (VLA-4/VCAM-1 Inhibition) as a Novel Regimen to Mobilize CD34+ Hematopoietic Stem Cells for Gene Therapies in Sickle Cell Disease (SCD)
Latest Information Update: 13 May 2025
At a glance
- Drugs Motixafortide (Primary) ; Natalizumab (Primary)
- Indications Sickle cell anaemia
- Focus Adverse reactions; Proof of concept
Most Recent Events
- 06 May 2025 Planned End Date changed from 31 Dec 2025 to 26 Jun 2025.
- 06 May 2025 Planned primary completion date changed from 31 Dec 2025 to 26 Jun 2025.
- 08 Apr 2025 Status changed from recruiting to active, no longer recruiting.