Trial Profile

FORAGER-1: A Phase 1, Open-Label, Multicenter Study of LOXO-435 (LY3866288) in Locally Advanced or Metastatic Solid Tumors Including Urothelial Cancer With FGFR3 Alterations

Status: Recruiting

Phase of Trial: Phase I

Latest Information Update: 27 Aug 2026

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At a glance

Drugs Vepugratinib (Primary) ; Enfortumab vedotin; Pembrolizumab
Indications Carcinoma; Solid tumours; Urogenital cancer
Focus Adverse reactions; First in man; Therapeutic Use
Acronyms FORAGER-1
Sponsors Eli Lilly and Company

Most Recent Events

20 Aug 2026 Planned number of patients changed from 535 to 677.
13 Oct 2025 According to an Eli Lilly and Company media release, data from this study will be presented at the European Society for Medical Oncology (ESMO) Annual Meeting, taking place October 17-21 in Berlin, Germany.
17 Apr 2025 Planned End Date changed from 1 Jun 2025 to 1 Jun 2027.

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