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FORAGER-1: A Phase 1, Open-Label, Multicenter Study of LOXO-435 (LY3866288) in Locally Advanced or Metastatic Solid Tumors Including Urothelial Cancer With FGFR3 Alterations

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Trial Profile

FORAGER-1: A Phase 1, Open-Label, Multicenter Study of LOXO-435 (LY3866288) in Locally Advanced or Metastatic Solid Tumors Including Urothelial Cancer With FGFR3 Alterations

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 24 Apr 2025

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At a glance

  • Drugs LOXO 435 (Primary) ; Enfortumab vedotin; Pembrolizumab
  • Indications Carcinoma; Solid tumours; Urogenital cancer
  • Focus Adverse reactions; First in man; Therapeutic Use
  • Acronyms FORAGER-1
  • Sponsors Eli Lilly and Company

Most Recent Events

  • 17 Apr 2025 Planned End Date changed from 1 Jun 2025 to 1 Jun 2027.
  • 17 Apr 2025 Planned primary completion date changed from 1 Jun 2025 to 1 Jun 2027.
  • 08 Apr 2025 Protocol has been amended to add cohorts in combination with Enfortumab Vedotin. Number of patients increased. Cohort A2 randomized.

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