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A Phase 2, Multicenter, Randomized, Open-Label, Active-Control Study of REGN9933, a Factor XI Monoclonal Antibody, for Prevention of Venous Thromboembolism After Elective, Unilateral, Total Knee Arthroplasty

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Trial Profile

A Phase 2, Multicenter, Randomized, Open-Label, Active-Control Study of REGN9933, a Factor XI Monoclonal Antibody, for Prevention of Venous Thromboembolism After Elective, Unilateral, Total Knee Arthroplasty

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 16 Dec 2025

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At a glance

  • Drugs REGN 9933 (Primary) ; Apixaban; Enoxaparin sodium
  • Indications Venous thromboembolism
  • Focus Therapeutic Use
  • Acronyms ROXI-VTE I
  • Sponsors Regeneron Pharmaceuticals

Most Recent Events

  • 08 Nov 2025 Results published in the Media Release
  • 19 Dec 2024 Results presented in a Regeneron Pharmaceuticals Media Release.
  • 04 Jun 2024 Status changed from active, no longer recruiting to completed.

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