Trial Profile

A Phase 1a/1b, Open-Label, Multi-Center, Dose Escalation and Expansion Study of HFB200603 (Anti-BTLA Antibody) as a Single Agent and in Combination With Tislelizumab (Anti-PD-1 Antibody) in Adult Patients With Advanced Solid Tumors

Status: Active, no longer recruiting

Phase of Trial: Phase I

Latest Information Update: 25 Nov 2025

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At a glance

Drugs HFB 200603 (Primary) ; Tislelizumab (Primary)
Indications Colorectal cancer; Gastric cancer; Malignant melanoma; Non-small cell lung cancer; Renal cell carcinoma; Solid tumours
Focus Adverse reactions; First in man
Sponsors HiFiBiO

21 Nov 2025 Status changed from recruiting to active, no longer recruiting.
25 Sep 2025 According to a HiFiBiO media release, data from this trial to be presented in the 2025 Annual Meeting of the European Society for Medical Oncology (ESMO), taking place October 17-21 in Berlin, Germany.
24 Sep 2025 New source identified and integrated (Clinical Trials Information System: CTIS2022-502891-22-00).

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