Trial Profile

A Proof of Concept Study of TBio-4101 (an Autologous Selected and Expanded Tumor Infiltrating Lymphocyte [TIL] Therapy) Using Short-Term Cultured, Selected Autologous TIL Following a Lymphodepleting Chemotherapy Regimen and Followed by IL-2 for Patients With Relapsed or Refractory Melanoma (Phase 1)

Status: Discontinued

Phase of Trial: Phase I

Latest Information Update: 21 Jan 2026

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At a glance

Drugs Cyclophosphamide (Primary) ; Interleukin-2 (Primary) ; TIDAL-01 (Primary) ; Fludarabine; Mesna
Indications Eye neoplasms; Malignant melanoma; Skin cancer; Uveal melanoma
Focus First in man; Proof of concept; Therapeutic Use

07 Jan 2026 Planned primary completion date changed from 1 Dec 2025 to 1 Jun 2026.
04 Feb 2025 Status changed from recruiting to discontinued.
22 Jan 2025 Planned primary completion date changed from 1 Dec 2024 to 1 Dec 2025.

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