Trial Profile

A Phase 1, Open-label, Dose-escalation, and Dose-expansion Study of BMF-500, an Oral Covalent FLT3 Inhibitor, in Adults With Acute Leukemia

Status: Recruiting

Phase of Trial: Phase I

Latest Information Update: 20 Jun 2025

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At a glance

Drugs BMF-500 (Primary)
Indications Acute myeloid leukaemia; Precursor cell lymphoblastic leukaemia-lymphoma
Focus Adverse reactions; First in man; Pharmacokinetics
Acronyms COVALENT-103
Sponsors Biomea Fusion

13 Jun 2025 Results presented in the Biomea Fusion media release.
14 May 2025 Results (As of 03Feb25, n=24) presented in the Biomea Fusion Media Release
14 May 2025 According to a Biomea Fusion media release, company announced that preliminary clinical data from the Phase I COVALENT-103 trial of BMF-500 in adults with acute leukemia (AL) were selected for a poster presentation at the European Hematology Association (EHA) 2025 Congress, taking place June 12-15 in Milan, Italy.

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