Trial Profile

A Phase 1 Dose Escalation and Expansion Study of Orca-Q, an Engineered Donor Graft Derived From Mobilized Peripheral Blood, in Recipients Undergoing Myeloablative Allogeneic Hematopoietic Cell Transplantation for Hematologic Malignancies

Status: Recruiting

Phase of Trial: Phase I

Latest Information Update: 19 Mar 2025

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At a glance

Drugs Orca-Q (Primary) ; Busulfan; Fludarabine; Thiotepa
Indications Acute biphenotypic leukaemia; Acute myeloid leukaemia; Myelodysplastic syndromes; Myelofibrosis; Precursor cell lymphoblastic leukaemia-lymphoma
Focus Adverse reactions; Therapeutic Use
Sponsors Orca Bio

08 Dec 2024 According to Orca Bio media release, data from the study were presented at the 66th American Society of Hematology (ASH) Annual Meeting.
08 Dec 2024 Preliminary Results (n=14) presented in the Orca Bio Media Release.
28 Mar 2024 Planned End Date changed from 1 Apr 2026 to 1 Apr 2028.

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