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A Phase 1, Open-label, Dose-escalation Study to Assess Safety and Pharmacokinetics of Nab-Sirolimus in Patients With Locally Advanced or Metastatic Solid Tumors and Moderate Liver Impairment

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Trial Profile

A Phase 1, Open-label, Dose-escalation Study to Assess Safety and Pharmacokinetics of Nab-Sirolimus in Patients With Locally Advanced or Metastatic Solid Tumors and Moderate Liver Impairment

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 17 Nov 2025

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At a glance

  • Drugs Sirolimus (Primary)
  • Indications Solid tumours
  • Focus Adverse reactions; Pharmacokinetics
  • Sponsors Whitehawk Therapeutics

Most Recent Events

  • 13 Nov 2025 Planned End Date changed from 1 Apr 2025 to 1 Aug 2026.
  • 13 Nov 2025 Planned primary completion date changed from 1 Apr 2025 to 1 Jun 2026.
  • 15 Dec 2023 Planned End Date changed from 1 Oct 2023 to 1 Apr 2025.

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