Trial Profile

Phase I/II Open Label Study Evaluating the Safety and Efficacy of Combining STAT3 Inhibition (TTI-101) With Anti-PD-1 Therapy (Pembrolizumab) in Patients With Recurrent or Metastatic (RM) Head and Neck Squamous Cell Carcinoma (HNSCC)

Status: Withdrawn prior to enrolment

Phase of Trial: Phase I/II

Latest Information Update: 13 Oct 2025

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At a glance

Drugs Pembrolizumab (Primary) ; TTI 101 (Primary)
Indications Carcinoma; Head and neck cancer; Solid tumours; Squamous cell cancer
Focus Therapeutic Use

30 Sep 2025 Status changed from not yet recruiting to withdrawn prior to enrolment.
24 Jan 2025 Planned End Date changed from 12 Aug 2026 to 30 Nov 2026.
24 Jan 2025 Planned primary completion date changed from 30 Nov 2025 to 30 Nov 2026.

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