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A Phase II Study of Induction Tucatinib and Trastuzumab With Total Neoadjuvant Therapy for Locally Advanced HER2-amplified Rectal Adenocarcinoma

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Trial Profile

A Phase II Study of Induction Tucatinib and Trastuzumab With Total Neoadjuvant Therapy for Locally Advanced HER2-amplified Rectal Adenocarcinoma

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 18 Mar 2026

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At a glance

  • Drugs Trastuzumab (Primary) ; Tucatinib (Primary) ; Fluorouracil; Folinic acid; Oxaliplatin
  • Indications Adenocarcinoma; Rectal cancer
  • Focus Therapeutic Use

Most Recent Events

  • 04 Mar 2026 Planned primary completion date changed from 24 Jun 2026 to 30 Jul 2027.
  • 11 Feb 2026 Planned End Date changed from 30 Dec 2026 to 31 Jul 2030.
  • 11 Feb 2026 Planned primary completion date changed from 30 Dec 2026 to 24 Jun 2026.

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