Trial Profile

A Phase 1 Dose Escalation Trial Evaluating an Intravenously Administered Recombinant Adeno-Associated Virus Serotype rh.74 (AAVrh.74) Vector Containing the Human Plakophilin-2a (PKP2a) Coding Sequence (RP-A601; AAVrh.74-PKP2a) in Subjects With Arrhythmogenic Cardiomyopathy Arising From Pathogenic PKP2 Variants (PKP2-ACM)

Status: Recruiting

Phase of Trial: Phase I

Latest Information Update: 20 Aug 2026

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At a glance

10 Aug 2026 According to a Rocket Pharmaceuticals media release, company is actively engaging with the FDA to seek alignment on the path to dosing additional patients and completing the pivotal Phase 2 trial and expects to provide an update on the regulatory pathway in the second half of 2026.
16 Apr 2026 Planned End Date changed from 1 Sep 2026 to 1 Sep 2029.
16 Apr 2026 Planned primary completion date changed from 1 Sep 2025 to 1 Sep 2028.

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