Trial Profile

This is a Phase II, open-label, multi-drug, multi-centre study designed to assess the efficacy, safety, tolerability, pharmacokinetics, and immunogenicity of novel combination therapies in participants with locally advanced unresectable or metastatic gastric or GEJ adenocarcinoma.

Status: Recruiting

Phase of Trial: Phase II

Latest Information Update: 20 Nov 2025

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At a glance

Drugs Rilvegostomig (Primary) ; Volrustomig (Primary) ; Capecitabine; Fluorouracil; Folinic acid; Oxaliplatin
Indications Adenocarcinoma; Gastric cancer; Oesophageal cancer
Focus Therapeutic Use
Acronyms GEMINI-Gastric
Sponsors AstraZeneca; AstraZeneca AB

17 Nov 2025 Planned End Date changed from 1 Jul 2027 to 28 Sep 2027.
29 Jun 2025 Planned End Date changed from 28 Jan 2027 to 1 Jul 2027.
29 Jun 2025 Planned primary completion date changed from 30 Jan 2026 to 3 Jul 2026.

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