Trial Profile

DETERMINE (Determining Extended Therapeutic Indications for Existing Drugs in Rare Molecularly Defined Indications Using a National Evaluation Platform Trial): An Umbrella-Basket Platform Trial to Evaluate the Efficacy of Targeted Therapies in Rare Adult, Paediatric and Teenage/Young Adult (TYA) Cancers With Actionable Genomic Alterations, Including Common Cancers With Rare Actionable Alterations

Status: Recruiting

Phase of Trial: Phase II/III

Latest Information Update: 04 Jun 2025

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At a glance

Drugs Alectinib (Primary) ; Atezolizumab (Primary) ; Cobimetinib (Primary) ; Entrectinib (Primary) ; Pertuzumab (Primary) ; Trastuzumab (Primary) ; Vemurafenib (Primary)
Indications Cancer; Haematological malignancies; Solid tumours
Focus Therapeutic Use
Acronyms DETERMINE

24 Oct 2023 Trial design presented at the 48th European Society for Medical Oncology Congress
16 Feb 2023 New trial record

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